Huntington’s disease (HD) is a rare, inherited brain disorder that slowly erodes a person’s ability to move, think, and regulate emotions. Often described as a “genetic time bomb,” HD can remain hidden for decades before symptoms appear, usually in mid-adulthood. Its progression is relentless, affecting not only the individual but also families and future generations. Understanding Huntington’s disease is crucial for early recognition, compassionate care, and informed decision-making. Causes and Risk Factors The Genetic Culprit Huntington’s disease is caused by a mutation in a single gene called HTT located on chromosome 4. This gene contains a sequence of DNA known as a CAG trinucleotide repeat. In people with HD, this sequence is abnormally expanded-typically 40 or more repeats-leading to the production of a toxic form of the huntingtin protein. This abnormal protein gradually damages and destroys nerve cells in specific brain regions, resulting in the symptoms of HD. Inherita...
"Disorder and Cure" offers in-depth articles on understanding and overcoming medical conditions, from diagnosis to recovery.